Granulocytes are maintained in developmental and storage pools. A subset of these cells differentiates and matures into the phagocytic cell lines, which include neutrophils, monocytes, basophils, and eosinophils. Its origin is the pluripotential stem cells located in the bone marrow. The granulocytic series is primarily involved in phagocytic activity. The granulocytic and lymphocytic series are the two WBC cell lines. The rate that new cells enter the circulation is usually in equilibrium with the rate of loss in tissues. WBCs reach their site of action through the circulation. Leukocytes primarily function extravascularly, and their function is closely integrated with the other types of white cells. Only 5% of the total lymphocytes in the body are in circulation. Because lymphocytes can freely leave and return to the circulation, the storage pools are less well defined. The WBC series has three morphologically indistinguishable cell types: B cells (humoral immunity), T cells (cellular immunity), and null cells. Walls MD, in Rosen's Emergency Medicine: Concepts and Clinical Practice, 2018 Anatomy and Physiology Nonmalignant disorders of leukocytes: granulocytes and monocytes. In: Clinical hematology and fundamentals of hemostasis. Cell biology, disorders of neutrophils, infectious mononucleosis, and reactive lymphocytosis. In: Rodak’s hematology clinical applications and principles. Historical perspective and clinical implications of the Pelger-Huet cell. Cunningham JM, Patnaik MM, Hammerschmidt DE, Vercellotti GM. Philadelphia, PA: Lippincott Williams & Wilkins 1999. In: Clinical hematology: theory and procedures. Nonmalignant Disorders of Granulocytes and monocytes. Pseudo-Pelger-Huet: Cytopenias often presentġ. Pseudo-Pelger-Huet may also be seen during infections, and drug interactions.Ĭongenital Pelger-Huet: Cytopenias often absent Psuedo Pelger-Huet may indicate leukocyte malignancies and myelodysplasia.Ĭongenital: Lamin β-receptor gene mutation.Īcquired (Pseudo-Pelger-Huet): Hematologic malignancies such as myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasms (MPNs). ![]() Pelger-Huet Anomaly is benign and cell function is normal. Pseudo Pelger-Huet: seen in leukocyte malignancies and Myelodysplastic Syndrome, hypogranulation and other Dy’s plastic features may be present, 10-30% of neutrophils are affected. Anomaly is differentiated from a left shift by displaying mature chromatin pattern, abundant cytoplasm (low nuclear:cytoplasmic ratio), mature granulation, and an absence of toxic changes.Ĭongenital Pelger-Huet: granulocytes show normal granulation, 50-90% of neutrophils are affected. Neutrophil nuclei appear hyposegmented – can appear as a single round nucleus (unilobed, homozygous Pelger-Huet Anomaly) or dumbbell shaped (bilobed, heterozygous Pelger-Huet Anomaly). From MLS Collection, University of Alberta. Images of Pelger-Huet Anomaly in various peripheral blood smears showing numerous hyposegmented neutrophils with mature clumped chromatin. \)Īn interactive or media element has been excluded from this version of the text.
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